Reactive Oxygen Species Deficiency Induces Autoimmunity with Type 1 Interferon Signature
نویسندگان
چکیده
منابع مشابه
Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species.
Here, we examine the mechanism by which plasmacytoid dendritic cells (pDCs) and type I interferons promote humoral autoimmunity. In an amyloid-induced experimental autoimmune model, neutrophil depletion enhanced anti-nuclear antibody development, which correlated with heightened IFN-γ production by natural killer (NK) cells. IFN-α/β produced by pDCs activated NK cells via IL-15 induction. Neutr...
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ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2014
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2013.5828